Stromal Gene Expression in Primary Breast Tumours That Metastasize to Bone

Grant number: BC021555

Abstract

PUBLIC ABSTRACT Breast cancer is a high incidence disease that can be treated effectively if detected early, before metastatic spread. After metastasis occurs, there are no effective treatments, and most patients who die of the disease have metastatic lesions in bone. Thus, it is important to determine the mechanisms by which a cell invades into the circulation and specifically migrates to the skeletal environment, causing a painful and debilitating condition. It is known that both tumor cells and the host tissue undergo a number of molecular changes to allow the tumor cell to reach and grow in the bone environment. The genes involved in this specific homing process to bone are important in ..

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University of Melbourne Researchers

Belinda Parker